Einstein is known for developing the theory of relativity , but he also made important contributions to the development of the theory of quantum mechanics. Relativity and quantum mechanics are together the two pillars of modern physics. His intellectual achievements and originality resulted in "Einstein" becoming synonymous with "genius". In , a year sometimes described as his annus mirabilis 'miracle year' , Einstein published four groundbreaking papers.
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PLOS for Public Library of Science is a nonprofit open-access science, technology, and medicine publisher with a library of open-access journals and other scientific literature under an open-content license. The publications are primarily funded by payments from the authors. Although tens of thousands signed the petition, most did not act upon its terms; and in August , Brown and Eisen announced that they would start their own nonprofit publishing operation. The PLOS organizers turned their attention to starting their own journal, along the lines of the UK -based BioMed Central , which has been publishing open-access scientific articles in the biological sciences in journals such as Genome Biology since As a publishing company, the Public Library of Science officially launched its operation on 13 October , with the publication of a print and online scientific journal entitled PLOS Biology , and has since launched seven more journals. The PLOS journals are what is described as "open-access content"; all content is published under the Creative Commons "attribution" license.
Tn5-mediated transposition of double-strand DNA has been widely utilized in various high-throughput sequencing applications. As a proof-of-concept application, we utilized this activity to replace the traditional library construction procedure of RNA sequencing, which contains many laborious and time-consuming processes. At the meantime, TRACE-seq enables a cost-effective one-tube library construction protocol and hence is more rapid within 6 hr and convenient. Taking advantage of this catalytic activity, transposases are widely used in many biomedical applications: for instance, an engineered, hyperactive Tn5 transposase from E.
Plan S is an initiative for open-access science publishing launched in   by "cOAlition S",  a consortium of national research agencies and funders from twelve European countries. The plan requires scientists and researchers who benefit from state-funded research organisations and institutions to publish their work in open repositories or in journals that are available to all by Major publishers have been planning to accommodate this mandate by offering or allowing open access options to authors.